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组蛋白伴侣<font color='red'>NAS</font>P调控组蛋白周转驱动PARP抑制剂耐药性的机制研究
PARP抑制剂(PARPi)在治疗同源重组缺陷肿瘤中取得重大突破,但耐药性仍是临床挑战。研究人员发现PARPi会触发癌细胞染色质组蛋白释放,而靶向组蛋白伴侣NASP可增强PARPi敏感性。[查看]
http://www.cxbio.com/Article/20250815_industrialnews_1.html
SCREEN-WELL(R) 激酶 抑制剂化合物库 SCREEN-WELL(R) Kinase Inhibitor library
SCREEN-WELL(R) 激酶 抑制剂化合物库 SCREEN-WELL(R) Kinase Inhibitor library,包含 80 种已知活性的激酶抑制剂。抑制剂溶于 DMSO 中,终浓度为 10 mM、有 100 μL 和 500 μL 两种规格。该化合物库可用于化学基因组学、药理分析等。[查看]
http://www.cxbio.com/Article/Kinase-Inhibitor-library_1.html
激酶分析筛选试剂盒 Fluorospark(R) Kinase/ADP Multi-Assay Kit
激酶分析筛选试剂盒 Fluorospark(R) Kinase/ADP Multi-Assay Kit,是富士胶片和光与日本东京大学新药研究机构共同研发的 ADP 荧光检测试剂盒。拥有高通量筛选(HTS)所必须的高灵敏度、高准确度、低成本、简便等特性。本产品不仅可检测激酶,同时可用于检测产生 ADP 的酶(如 ATP 酶、乙酰基— CoA 羧化酶)的活性。[查看]
http://www.cxbio.com/Article/Fluorospark-kit_1.html
PUREfrex(R) 2.0 PUREfrex(R) 酶无细胞蛋白合成试剂盒
PUREfrex(R) 2.0 改良了 PUREfrex(R) 1.0(#PF001-0.25)的反应液成分,保留 PUREfrex(R) 特点(RNase和LPS 等的污染少)的同时提高了合成效率。适用于需要大量蛋白的实验,如蛋白的功能评估等。[查看]
http://www.cxbio.com/Article/PUREfrex2_1.html
细胞表面的RNA结合蛋白是对抗癌症的关键
摘要:在急性髓性白血病(AML)细胞表面发现了一种易于药物治疗的靶点——在多个体内模型中,单克隆抗体抑制了白血病,没有明显的副作用。 2021年,由Ryan Flynn医学博士和他的导师、诺贝尔奖得主Carolyn Bertozzi博士领导的研究,揭开了生物学的新篇章,描绘了细胞表面上一种新的参与者:glycoRNAs。最近在《细胞》杂志上,Flynn和他的同事们扩展了这一发现,他们发现糖RNA在细胞表面与RNA结合蛋白形成高度组织化的簇。这些簇似乎调节细胞与环境之间的通讯。 现在,[查看]
http://www.cxbio.com/Article/xbbmdrnajhdbsdkazdgj_1.html
P<font color='red'>NAS</font>:万万没想到,结核杆菌自己提供促进空气传播的基因
研究人员来自威尔·康奈尔医学院和麻省理工学院,他们发现结核杆菌依赖于一组基因,这些基因帮助它们在咳嗽、打喷嚏或说话时从一个人的肺部传播到另一个人的肺部。这项研究为结核病治疗提供了新的靶点,有望同时治疗感染并阻止细菌传播。[查看]
http://www.cxbio.com/Article/20250313_industrialnews_1.html
P<font color='red'>NAS</font>:将侵袭性癌细胞重新编程为无害的癌细胞
加州大学洛杉矶分校(UCLA)的科学家们发现了一种治疗胶质母细胞瘤(最致命的脑癌类型)的潜在新策略,即通过重新编程将具有侵略性的癌细胞转变为无害的细胞。相关研究结果发表在《美国国家科学院院刊》上,研究表明,将放疗与一种名为福斯可林的植物衍生化合物相结合,可以迫使胶质母细胞瘤细胞进入休眠状态,使其无法分裂或扩散。[查看]
http://www.cxbio.com/Article/pnasjqxxaxbzxbcwwhda_1.html
P<font color='red'>NAS</font>:细胞间mRNA转移改变人类多能干细胞状态
日本东京科学研究所Takanori Takebe教授领导的研究小组研究了不同类型干细胞之间mRNA转移的机制和作用。他们的研究结果发表在2025年1月22日的《美国国家科学院院刊》。[查看]
http://www.cxbio.com/Article/pnasxbjmrnazygbrldng_1.html
《NBE》小环状RNA疫苗:癌症免疫治疗的新曙光
研究人员在国际知名期刊《Nature Biomedical Engineering》上发表了一篇题为“Small circular RNAs as vaccines for cancer immunotherapy”的论文。该研究在癌症免疫治疗领域取得了突破性进展,为开发新型癌症疫苗提供了重要的理论依据和技术支持。这一成果不仅展示了小环状RNA(circRNA)在癌症治疗中的巨大潜力,还为未来癌症疫苗的研发提供了新的思路和方向[查看]
http://www.cxbio.com/Article/nbexhzrnaymazmyzldxs_1.html
《Cell》一种small RNA有潜力逆转衰老
发表在《Cell》杂志上的一篇文章中,科学家们把注意力集中在一种小核核RNAs (snoRNAs)上,这种RNA通过抑制核糖体的产生而使细胞停止分裂除了扩大科学家对这类生物分子在细胞衰老中的作用的了解之外,这些发现还可以为设计新的核糖体疾病治疗方法提供信息。[查看]
http://www.cxbio.com/Article/cellyzsmallrnayqlnzs_1.html
P<font color='red'>NAS</font>首次表明:人体组织中驻留在肺部的NK细胞在代谢方面与血液中循环的NK细胞不同
圣詹姆斯医院都柏林三一学院的研究人员对一种以前基本上不为人知的、但至关重要的“自然杀手”(NK)免疫细胞的行为和代谢功能提供了重要的见解。他们的研究结果发表在今天(2024年10月10日星期四)的《美国国家科学院院刊》(PNAS)上,为进一步探索NK细胞为一系列肺部疾病(包括慢性阻塞性肺疾病(COPD)、癌症和结核病)的未来治疗和疗法的发展奠定了基础。[查看]
http://www.cxbio.com/Article/20241016_inustrialnews_1.html
P<font color='red'>NAS</font>:有缺陷的DNA修复机制与亨廷顿氏病
麦克马斯特大学的研究人员发现,亨廷顿舞蹈症患者体内突变的蛋白质不能像预期的那样修复DNA,从而影响了脑细胞自愈的能力。这项研究于2024年9月27日发表在美国国家科学院院刊上,发现亨廷顿蛋白有助于产生对修复DNA损伤很重要的特殊分子。这些分子被称为Poly [ADP-ribose],聚集在受损的DNA周围,像一张网一样,吸引修复过程所需的所有因素。[查看]
http://www.cxbio.com/Article/pnasyqxddnaxfjzyhtds_1.html
P<font color='red'>NAS</font>:细胞在重编程过程中难以完全改变身份的原因
希伯来大学的Yosef Buganim教授和Howard Cedar教授以及宾夕法尼亚大学的Ben Stanger教授领导的一项新研究发表在《美国国家科学院院刊》上,该研究为将一种特化细胞转化为另一种特化细胞的挑战提供了新的视角,这是再生医学进步的关键过程。尽管最近取得了进展,但研究人员发现,维持重编程细胞新身份的一个关键障碍在于它们原来的DNA甲基化模式——这是定义细胞身份的关键标记。[查看]
http://www.cxbio.com/Article/pnasxbzzbcgcznywqgbs_1.html
P<font color='red'>NAS</font>提出新视角:低温下RNA的新生物化学
核糖核酸(RNA)是一种在生物遗传学中具有重要功能的生物分子,在生命的起源和进化中起着关键作用。RNA的组成与DNA非常相似,它能够执行各种生物功能,这取决于它的空间构象,即分子在自身上折叠的方式。现在,发表在《美国国家科学院院刊》(PNAS)上的一篇论文首次描述了RNA在低温下折叠的过程如何为研究地球上的原始生物化学和生命进化开辟了一个新的视角。[查看]
http://www.cxbio.com/Article/pnastcxsjdwxrnadxswh_1.html
《P<font color='red'>NAS</font>》AlphaFold2助力揭示细胞质量控制的关键蛋白复合物
我们的身体有一个质量控制系统,可以识别错误折叠的蛋白质,并将它们标记为额外的折叠工作或破坏,但是,这个质量控制过程究竟是如何起作用的,我们还不完全清楚。马萨诸塞大学阿姆赫斯特分校(University of Massachusetts Amherst)的研究人员发现了所有行为发生的“热点”,在我们对这种质量控制系统如何工作的理解上取得了重大飞跃。这项研究最近发表在《PNAS》上。[查看]
http://www.cxbio.com/Article/pnasalphafold2zljsxb_1.html
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Cholesterol Dehydrogenase Amano 5
Glucose Dehydrogenase Amano 2
Glucose Dehydrogenase Amano 2
Lactate Dehydrogenase Amano 3
Lactate Dehydrogenase Amano 3
Malate Dehydrogenase Amano 3
Malate Dehydrogenase Amano 3
Penicillinase
Penicillinase
Penicillinase Bulk Powder
Penicillinase Bulk Powder
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactateoxidase),from Pediococcus species, lyophilizate
Lactate 2-Monooxygenase (Lactateoxidase),from Pediococcus species, lyophilizate
Mab<CK-MM> Mix creatinine kinase isoenzyme MM
Mab Mix creatinine kinase isoenzyme MM
Creatine Kinase-MM Monoclonal Antibody (14.15)
Creatine Kinase-MM Monoclonal Antibody (14.15)
Creatine Kinase-MM Monoclonal Antibody (14.5)
Creatine Kinase-MM Monoclonal Antibody (14.5)
Creatine Kinase-MM Monoclonal Antibody (14.52)
Creatine Kinase-MM Monoclonal Antibody (14.52)