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《P<font color='red'>NAS</font>》从过度反应蛋白合成到认知障碍,敲除1个基因即可
日本理研研究所的研究人员发现了蛋白质合成与神经发育障碍之间的联系,发现蛋白质生产过程中过度活跃的质量控制过程会抑制神经生长和交流,导致认知功能障碍。这为治疗这类疾病开辟了潜在的新途径。[查看]
http://www.cxbio.com/Article/20230727_1.html
P<font color='red'>NAS</font>新研究:致病菌利用肠道黏液层中的一种糖来感染肠道
发表在《美国国家科学院院刊》(PNAS)上的研究结果表明,肠道细菌感染和一系列与肠道细菌有关的慢性疾病,包括炎症性肠病(IBD)、乳糜泻、肠易激综合征和短肠综合征,都有可能成为治疗目标。[查看]
http://www.cxbio.com/Article/pnasSialicacid_1.html
P<font color='red'>NAS</font>:基于CRISPR/cas9的基因驱动可以抑制农业害虫
北卡罗来纳州立大学研究人员已经开发出一种基于CRISPR/Cas9的“归巢基因驱动系统”,可以用来抑制斑翅果蝇 Drosophila suzukii 的数量。研究人员开发了双CRISPR基因驱动系统,针对一种特定的斑翅果蝇基因,这种基因被称为doublesex,对果蝇的性发育很重要。[查看]
http://www.cxbio.com/Article/pnasjycrisprcas9djyq_1.html
IL-17蛋白对皮肤老化的关键作用
来自巴塞罗那生物医学研究所(IRB Barcelona)与国家基因组分析中心(CNAG)合作的一组科学家发现,IL-17蛋白在皮肤老化中起着核心作用。这项研究由巴塞罗那IRB的Guiomar Solanas博士、Salvador Aznar Benitah博士和CNAG的Holger Heyn博士领导,强调了Il -17介导的衰老过程到炎症状态。[查看]
http://www.cxbio.com/Article/il17dbdpflhdgjzy_1.html
P<font color='red'>NAS</font>意外发现线粒体的更多功能:细胞可塑性
长期以来,研究人员一直认为,一旦细胞开始分化,长成皮肤细胞、肝细胞或神经元,这条道路就不能改变。但在过去的二十年里,科学家们意识到这条途径要复杂得多。现在,密歇根大学(University of Michigan)的一个研究小组以斑马鱼为模型,发现人体线粒体(细胞内为身体产生能量的细胞器)中的一个环可能允许细胞在分化的道路上后退。他们的研究结果发表在《美国国家科学院院刊》上。[查看]
http://www.cxbio.com/Article/pnasywfxxltdgdgnxbks_1.html
《P<font color='red'>NAS</font>》对抗慢性炎症和传染病,如何调动我们的细胞的愈合能力
昆士兰大学分子生物科学研究所的Kaustav Das Gupta教授和Matt Sweet博士发现,免疫细胞中从葡萄糖中提取的一种分子5-磷酸核酮糖具有阻止细菌生长和抑制炎症反应的能力。这一发现代表了未来治疗方法发展的关键一步,可以训练免疫细胞。[查看]
http://www.cxbio.com/Article/HDAC7switch_1.html
P<font color='red'>NAS</font>突破性新发现:帮助细菌在人类呼吸道定植的CPS特征
新加坡国立大学医学院(NUS Medicine)的科学家们在一项突破性的发现中,发现了帮助细菌在人类呼吸道定植的CPS的特征。研究表明,CPS胶囊的结构及其连接和组合类型在允许细菌更好地附着在人类上呼吸道和下呼吸道内壁上并存活方面起着重要作用。[查看]
http://www.cxbio.com/Article/pnastpxxfxbzxjzrlhxd_1.html
CAR-T疗法创始人P<font color='red'>NAS</font>发文:实体肿瘤治疗曙光出现?利用“组合拳”帮助T细胞
发表在《美国国家科学院院刊》(PNAS)上的研究结果表明,靶向控制炎症相关基因功能的两种调节因子,可使模型中的T细胞至少增加10倍,从而增强抗肿瘤免疫活性和持久性。[查看]
http://www.cxbio.com/Article/cartlfcsrpnasfwstzlz_1.html
《P<font color='red'>NAS</font>》科学家解开细胞存活之谜
拉霍亚免疫研究所(LJI)的研究人员终于发现了一种名为O-GlcNAc转移酶(OGT)的酶在维持细胞健康中的作用。这些发现发表在《美国国家科学院院刊》(Proceedings of The National Academies of Sciences)上,为细胞生物学提供了至关重要的见解,并可能为重大医学突破铺平道路。[查看]
http://www.cxbio.com/Article/pnaskxjjkxbchzm_1.html
《Cell》深度挖掘人类RNA病毒的远亲——类病毒
一组研究人员开发了一种计算方式,以识别和更好地理解类病毒和类病毒共价封闭环状RNA (cccRNAs,也简称为环状RNAs)。[查看]
http://www.cxbio.com/Article/cellsdwjrlrnabddyqlb_1.html
P<font color='red'>NAS</font>:最新发现!常见的甜味剂阿斯巴甜或与焦虑症发生直接相关
来自佛罗里达州立大学等机构的科学家们通过研究发现了名为阿斯巴甜(aspartame)的人工甜味剂或与小鼠机体出现的焦虑症样行为有关,阿斯巴甜是一种在近5000种减肥食物和饮料中所使用的人工甜味剂。[查看]
http://www.cxbio.com/Article/pnaszxfxcjdtwjasbthy_1.html
《P<font color='red'>NAS</font>》首次发现,一种专吃病毒为生的微生物
内布拉斯加-林肯大学的研究人员发现,微小的纤毛虫可以吃掉大量与它们共享水生栖息地的传染性氯病毒,这是一个值得《吃豆人》的转折。该团队的实验室实验还首次表明,只含病毒的饮食(该团队称之为“病毒性”)足以促进生物体的生理生长,甚至种群增长。[查看]
http://www.cxbio.com/Article/pnasscfxyzzcbdwsdwsw_1.html
研究人员发现了非酒精性脂肪性肝炎的新分子靶点
来自复旦大学中山医院和上海交通大学附属第六人民医院的研究人员和其他合作者,通过三种饮食或化合物诱导的小鼠慢性肝炎症和损伤模型,共同确定了NASH发病的一种新的分子机制。本研究证实了IGF2BP2是NASH发生发展过程中的关键调控因子。[查看]
http://www.cxbio.com/Article/yjryfxlfjjxzfxgydxfz_1.html
P<font color='red'>NAS</font>揭示了人类内源性逆转录酶的结构
根据罗格斯大学的一项研究表明,人类内源性逆转录酶的晶体结构与HIV逆转录酶相似,HIV逆转录酶是一种众所周知的易处理药物靶标,它将有助于设计治疗癌症和其他疾病的药物。[查看]
http://www.cxbio.com/Article/pnasjslrlnyxnzlmdjg_1.html
六年半攻关!华东师大科学家P<font color='red'>NAS</font>发文:给细胞“喝红酒”可调控肿瘤免疫治疗
近日,华东师范大学生命科学学院、上海市调控生物学重点实验室、华东师范大学医学合成生物学研究中心叶海峰研究员团队经过六年半科研攻关,联合在《PNAS》杂志发表了一篇文章,该研究为如何缓解CAR-T疗法中的细胞因子风暴、肿瘤溶解综合征等致命副作用提供了新的思路。[查看]
http://www.cxbio.com/Article/qhkystcartxblfzwsylz_1.html
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