药物代谢和药物相互作用体外研究试剂
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Product Summary
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1) CYPxxxR Bactosomes (human) 人细胞色素cytochrome P450 (CYP)
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Human CYP co-expressed with human NADPH-CYP reductase in E. coli
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Enzyme
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Product Description
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CYP1A1
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CYP1A1R Bactosomes
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CYP1A1LR Bactosomes
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CYP1A2
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CYP1A2R Bactosomes
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CYP1A2LR Bactosomes
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CYP1B1.1
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CYP1B1LR Bactosomes
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CYP1B1.3
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CYP1B1*3LR Bactosomes
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CYP1B1.4
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CYP1B1*4LR Bactosomes
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CYP2A6
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CYP2A6R Bactosomes
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CYP2A13
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CYP2A13LR Bactosomes
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CYP2A13R Bactosomes
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CYP2B6
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CYP2B6BR Bactosomes
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CYP2B6R Bactosomes
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CYP2B6LR Bactosomes
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CYP2C8
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CYP2C8BR Bactosomes
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CYP2C8BLR Bactosomes
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CYP2C8R Bactosomes
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CYP2C8LR Bactosomes
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CYP2C9.1
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CYP2C9BHR Bactosomes
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CYP2C9BR Bactosomes
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CYP2C9HR Bactosomes
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CYP2C9R Bactosomes
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CYP2C9.2
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CYP2C9*2BR Bactosomes
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CYP2C9*2R Bactosomes
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CYP2C9.3
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CYP2C9*3BR Bactosomes
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CYP2C9*3R Bactosomes
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CYP2C18
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CYP2C18LR Bactosomes
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CYP2C19
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CYP2C19R Bactosomes
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CYP2C19LR Bactosomes
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CYP2D6.1
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CYP2D6R Bactosomes
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CYP2D6LR Bactosomes
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CYP2D6.2
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CYP2D6*2R Bactosomes
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CYP2D6.10
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CYP2D6*10R Bactosomes
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CYP2D6.39
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CYP2D6*39R Bactosomes
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CYP2E1
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CYP2E1BR Bactosomes
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CYP2E1R Bactosomes
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CYP2J2
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CYP2J2LR Bactosomes
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CYP3A4
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CYP3A4BR Bactosomes
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CYP3A4BLR Bactosomes
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CYP3A4R Bactosomes
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CYP3A4LR Bactosomes
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CYP3A5
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CYP3A5BR Bactosomes
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CYP3A5BLR Bactosomes
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CYP3A5R Bactosomes
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CYP3A5LR Bactosomes
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CYP4A11
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CYP4A11BR Bactosomes
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CYP4A11R Bactosomes
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CYP4A11LR Bactosomes
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CYP4F2
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CYP4F2BLR Bactosomes
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All the above products are supplied at 1 nmol CYP per vial.
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2) CYPxxxR Easy CYP Bactosomes (human) 人细胞色素
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Human CYP co-expressed with human NADPH-CYP reductase in E. coli
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Enzyme
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Product Description
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CYP1A1
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CYP1A1R EasyCYP Bactosomes
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CYP1A1LR EasyCYP Bactosomes
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CYP1A2
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CYP1A2R EasyCYP Bactosomes
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CYP1A2LR EasyCYP Bactosomes
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CYP1B1.1
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CYP1B1LR EasyCYP Bactosomes
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CYP1B1.3
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CYP1B1*3LR EasyCYP Bactosomes
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CYP2A6
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CYP2A6R EasyCYP Bactosomes
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CYP2A13
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CYP2A13R EasyCYP Bactosomes
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CYP2A13LR EasyCYP Bactosomes
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CYP2B6
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CYP2B6BR EasyCYP Bactosomes
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CYP2B6R EasyCYP Bactosomes
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CYP2B6LR EasyCYP Bactosomes
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CYP2C8
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CYP2C8BR EasyCYP Bactosomes
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CYP2C8BLR EasyCYP Bactosomes
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CYP2C8R EasyCYP Bactosomes
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CYP2C8LR EasyCYP Bactosomes
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CYP2C9.1
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CYP2C9BHR EasyCYP Bactosomes
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CYP2C9BR EasyCYP Bactosomes
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CYP2C9HR EasyCYP Bactosomes
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CYP2C9R EasyCYP Bactosomes
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CYP2C9.2
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CYP2C9*2BR EasyCYP Bactosomes
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CYP2C9*2R EasyCYP Bactosomes
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CYP2C9.3
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CYP2C9*3BR EasyCYP Bactosomes
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CYP2C9*3R EasyCYP Bactosomes
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CYP2C18
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CYP2C18LR EasyCYP Bactosomes
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CYP2C19
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CYP2C19R EasyCYP Bactosomes
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CYP2C19LR EasyCYP Bactosomes
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CYP2D6.1
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CYP2D6R EasyCYP Bactosomes
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CYP2D6LR EasyCYP Bactosomes
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CYP2D6.2
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CYP2D6*2R EasyCYP Bactosomes
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CYP2D6.10
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CYP2D6*10R EasyCYP Bactosomes
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CYP2D6.39
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CYP2D6*39R EasyCYP Bactosomes
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CYP2E1
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CYP2E1BR EasyCYP Bactosomes
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CYP2E1R EasyCYP Bactosomes
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CYP2J2
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CYP2J2LR EasyCYP Bactosomes
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CYP3A4
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CYP3A4BR EasyCYP Bactosomes
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CYP3A4BLR EasyCYP Bactosomes
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CYP3A4R EasyCYP Bactosomes
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CYP3A4LR EasyCYP Bactosomes
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CYP3A5
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CYP3A5BR EasyCYP Bactosomes
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CYP3A5BLR EasyCYP Bactosomes
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CYP3A5R EasyCYP Bactosomes
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CYP3A5LR EasyCYP Bactosomes
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CYP4A11
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CYP4A11BR EasyCYP Bactosomes
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CYP4A11R EasyCYP Bactosomes
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CYP4A11LR EasyCYP Bactosomes
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CYP4F2
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CYP4F2BLR EasyCYP Bactosomes
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EasyCYP Bactosomes are prepared to a standard specification:
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1 nmol CYP per ml; 10 mg total protein per ml; 0.5 nmol CYP per vial
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3) Bactosome kits
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Product Description
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Contents
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Low Reductase Bactosome Kit
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1 vial of each of the following Bactosomes:
CYP1A2LR (CYP012); CYP2C9R (CYP006); CYP2C19LR (CYP028); CYP2D6LR (CYP013); CYP3A4LR (CYP010); Control (CYP003) |
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High Reductase Bactosome Kit
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1 vial of each of the following Bactosomes:
CYP1A2R (CYP001); CYP2C9HR (CYP019) CYP2C19R (CYP008); CYP2D6R (CYP007) CYP3A4R (CYP002); Control (CYP003) |
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4) CYPxxxR Bactosomes (dog)
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Dog CYP co-expressed with dog NADPH-CYP reductase in E. coli
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Enzyme
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Product Description
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CYP1A1
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Dog CYP1A1LR Bactosomes
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CYP1A2
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Dog CYP1A2LR Bactosomes
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CYP2B11
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Dog CYP2B11LR Bactosomes
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CYP2C21
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Dog CYP2C21LR Bactosomes
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CYP2C41
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Dog CYP2C41LR Bactosomes
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CYP2D15
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Dog CYP2D15LR Bactosomes
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CYP3A12
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Dog CYP3A12LR Bactosomes
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CYP3A26
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Dog CYP3A26LR Bactosomes
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All the above products are supplied at 1 nmol CYP per vial.
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5) Control preparations
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Product Description
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Size
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Control Bactosomes
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10 mg protein
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Control EasyCYP Bactosomes
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5 mg protein
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Reductase Bactosomes
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4 nmol reductase
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Control cytosol
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1 mg protein
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Control EasyCYP Bactosomes are supplied at a standard protein concentration of 10 mg per ml.
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Control cytosol is supplied at a standard protein concentration of 10 mg per ml.
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6) Other enzymes
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Product Description
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Size
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Human SULT1A1*1
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1 mg cytosolic
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Human SULT1A1*2
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1 mg cytosolic
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Human SULT1A2
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1 mg cytosolic
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Human SULT1A3
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1 mg cytosolic
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Human SULT1B1
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1 mg cytosolic
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Human SULT1C2
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1 mg cytosolic
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Human SULT1C4
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1 mg cytosolic
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Human SULT1E1
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1 mg cytosolic
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Human SULT2A1
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1 mg cytosolic
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Human GSTA1
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1 mg cytosolic
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Human GSTM1
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1 mg cytosolic
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Human aldehydeoxidase
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250 μl cytosoli
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Human aldehydedehydrogenase 1A1
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1 mg cytosolic
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Human carboxylesterase 1 (CES1)
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1 mg membran
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Human carboxylesterase 2 (CES2)
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1 mg membran
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Human UGT1A6 Bactosomes
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5 mg membran
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7) Antibodies (other than Nosan antibodies)
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Product Description
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Size
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Pre-immune sheep serum
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50 μl
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Polyclonal sheep anti-rat UGT antiserum
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50 μl
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Polyclonal sheep anti-human SULT1A3 antiserum
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50 μl
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| 8) Chemicals | ||
| Product Description | Size | |
| 4’-hydroxydiclofenac, > 98% | 0.1 mg | CYP2C9 metabolite of diclofenac |
| 5 mg | ||
| 6α-hydroxypaclitaxel, > 97% | 0.1 mg | CYP2C8 metabolite of paclitaxel |
| 5 mg | ||
| [1-14C] lauric acid, > 98%, 49.4 mCi/mmol | 1.85 MBq(50 μCi) | Substrate for CYP2E1 and CYP4A11. |
| [1-14C] 11-hydroxylauric acid, > 98%, 51.8 mCi/mmol | 1.85 MBq(50 μCi) | CYP2E1 metabolite of lauric acid (minor metabolite of CYP4A11). |
| [1-14C] 12-hydroxylauric acid, > 98%, 50.8 mCi/mmol | 1.85 MBq | CYP4A11 metabolite of lauric acid. |
| Tolbutamide, > 98% | 100 mg | Substrate for CYP2C. |
| Hydroxytolbutamide, > 98% | 10 mg | CYP2C metabolite of tolbutamide. |
| Carboxytolbutamide, > 98% | 10 mg | Metabolite of tolbutamide. |
| Carboxytolbutamide methyl ester, > 98% | 10 mg | Derivative of carboxytolbutamide, a metabolite of tolbutamide. |
| Tolbutamide kit (containsTolbutamide Hydroxytolbutamide Carboxytolbutamide Carboxytolbutamide methyl ester), > 98% | 100 mg of tolbutamide, 10 mg each of metabolites. | Tolbutamide Hydroxytolbutamide Carboxytolbutamide >Carboxytolbutamide methyl ester |
| 7-ethoxyresorufin, > 98% | 10 mg | Substrate for CYP1A1, CYP1A2 and CYP1B1. |
| Resorufin, > 98% | 100 mg | CYP1A1, CYP1A2 and CYP1B1 metabolite of 7-ethoxyresorufin. |
| 7-benzyloxyquinoline (7BQ), > 98% | 10 mg | Substrate for CYP3A4. |
| 7-hydroxyquinoline (7HQ), > 98% | 10 mg | Metabolite of 7-BQ. |
| [3-14C] 7-ethoxycoumarin, 46.0 mCi/mmol, > 99% | 1.85 MBq (50 μCi) | CYP substrate |
| MAMC, > 98% | 10 mg | Substrate for CYP2D6. |
| 25 mg | ||
| HAMC, > 98% | 10 mg | CYP2D6 metabolite of MAMC. |
| 7-methoxy-4-(trifluoromethyl)-coumarin (MFC), > 98% | 10 mg | Substrate for CYP2C9. |
| 25 mg | ||
| 7-benzyloxy-4-(trifluoromethyl)-coumarin (BFC), > 98% | 10 mg | Substrate for CYP3A4. |
| 25 mg | ||
| 7-hydroxy-4-(trifluoromethyl)-coumarin (HFC), > 98% | 10 mg | Metabolite of MFC and BFC. |
| Omeprazole, > 98% | 1 g | Substrate of CYP2C19. |
| 3-O-methylfluorescein, > 98% | 10 mg | Substrate of CYP1A1 and CYP2C19. |
| 25 mg | ||
| Tienilic acid, > 98% | 10 mg | Mechanism-based inhibitor of CYP2C9. |
| 25 mg | ||
| Paclitaxel, > 98% | 25 mg | Substrate of CYP2C8. |
| 100 mg | ||
| Ketoconazole, > 98% | 100 mg | CYP3A4 inhibitor. |
| 1 g | ||
| Diclofenac, > 98% | 10 g | Substrate of CYP2C9 and CYP2C18. |
| Amodiaquine dihydrochloride dihydrate, > 98% | 5 g | Substrate of CYP2C8. |
| Desethylamodiaquine, > 98% | 10 mg | CYP2C8 metabolite of amodiaquine. |
| 25 mg | ||
| Terfenadine, > 98% | 5 g | Substrate of CYP3A4 and CYP2J2 |
| (-)-N-3-benzylphenobarbital, > 98% | 10 mg | Specific inhibitor of CYP2C19. |
| 25 mg | ||
| Montelukast sodium | 10 mg | Inhibitor of CYP2C8. |
| 25 mg | ||
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