Custom Synthesis of modified PEGs

来源：seebio.cn作者：西宝生物人气：-发表时间：2012-06-21 11:13:24【大中小】

Seebio Biotech, Inc. provides a variety of modified PEGs, for example, single functional group PEGs (mPEG), symmetry double functional group PEGs, asymmetric double functional group PEGs, multi-arm PEGs, PEG hybrid system and other derivatives.

mPEG、mPEG-NH2、mPEG-SS、mPEG-SC、mPEG2-NHS、mPEG-SPA、mPEG-ALD、mPEG-MAL、HO-PEG-COOH、mPEG-b-PS、mPEG-b-PI、mPEG-b-PAN、mPEG-b-PCL、mPEG-b-PMMA、α-hydroxyl-PEG-ω- amide、 mPEG-carboxyl、mPEG- cyan、hyperbranched polyglycerol , etc.

Functional groups include:
Maleimide(MAL),
NHS este(succinimidyl, SCM, SC, SG-glutarate, SS-succinate),
ortho-Pyridyldisulfide(OPSS),
n-Succinimidyl-3-(2-pyridyldithiol)propionate (SPDP),

Fluorescein (FITC),
Biotin,
Silane,
Nitrophenyl carbonate(NPC),
Amine (NH2, Boc or Fmoc),
Acid (COOH),
Lipid (DSPE),
Aldehyde,
Isocyanate (NCO),
Isothiocyanate (NCS),
Vinylsulfone (VS),
Hydrazide,
Acrylate (acryloyl),
Epoxide,
Succinic and Glutaric acid,
Tosylate and Mesylate

Custom synthesis of a varity of Functional Group Modified PEGs derivatives is AVAILABLE.

1.mPEG (monomethoxypoly(ethylene glycol)) or mPEO (monomethoxypoly (ethylene oxide))
CH3O-(CH2CH2O)n-CH2CH2OH
mPEG with low diol content, assay of diol <5%, Disperse(PDI):1.04~1.1
Time required : about 2 weeks

2.mPEG-NH2 or mPEG-amide
CH3O-(CH2CH2O)n-CH2CH2-NH2
CH3O-(CH2CH2O)n-CH2CH2CH2-NH2
Purity: ~90%
Time required : about 2 weeks

3. mPEG-SS ( mPEG-succinimidyl succinate)
Purity:>95%。
Time required : about 2 weeks

4. mPEG-SC ( mPEG-succinimidyl carbonate)
purity: >95%.
Time required : about 2 weeks

5. mPEG2-NHS (mPEG2- N-hydroxysuccinimde)
Purity: >95%。
Time required : about 3 weeks

6. mPEG-SPA ( mPEG-succinimidyl propionate)
mPEG-SPA assay: ~95％。
Time required : about 4 weeks

7. mPEG-ALD( mPEG-aldehyde)
purity: ~80%。

8. mPEG-MAL ( mPEG- maleimide)
Purity: ~80%。
Time required : 3 weeks

9. HO-PEG-COOH (α-hydroxyl-PEG-ω- carboxyl)
Time required : 3 weeks

10. mPEG-b-PS (mPEG-block- polystyrene)；
Time required : 3 weeks

11. mPEG-b-PI (mPEG-block- polyisoprene)；
Time required : 3 weeks

12. mPEG-b-PAN (mPEG-block- polyacrylonitrile)；
Time required : 3 weeks

13. mPEG-b-PCL (mPEG-block- poly(ε-caprolactone))；
Time required : 1 week

14. mPEG-b-PMMA (mPEG-block- poly(methyl methacrylate))；
Time required : 3 weeks

15. HO-PEG-OH (HO-(CH2CH2O)n-CH2CH2OH)
(Disperse(PDI):<1.15), various molecular weight available；
Time required : about 2 weeks

16. HO-PEG-NH2 (α-hydroxyl-PEG-ω- amide)
Time required : about 3 weeks

17. mPEG-carboxyl, various molecular weight available, purity: >95%。

18. mPEG- cyan, various molecular weight available, purity: >95%。

19. mPEG3-COOH 和mPEG3-NHS；
Time required : 3 weeks

20. Triple arm PEG and Tetra arm PEG (All terminal group are hydroxy group.)
Various molecular weight available;
Time required : 3 weeks

21.Hyperbranched poly glycerol hPG (hyperbranched poly(glycerol).
Various molecular weight Hyperbranched poly glycerol PG available
Time required : 3 weeks

Features & Tech Advantages

1. Multiple functional group modified service with a good property and high purity, Mw: 500-80,000, Disperse(PDI) <1.05 (PDI of general market product: 1.60);
2. Simplified manufacture process, low impurity, stable quality;
3. Batch production, cost under control;
4. More than 800 different grades available;
5. Specific grade synthesis acceptable.

Related Products

1、Single Functional Group PEGs (mPEG-R)

R:	-CH₂NH₂；-COOH；-CH₂CH₂COOH；-EPMAL；-SC；Biotin
	-PPMAL；-SPA；-OCOOPhNO₂；-CHO；-VS；-S-S-Pyridine；-Thiol
	-CH(OEt)₂；-SH；-SS；-SG；-SCM；-OTS；-ButyrALD； -ALD；-AC； -Alkyne；-Azide； -Epoxide；-Hydrazide；-NCO；-NPC；-OPSS；SG；-Silane；-VS

2、Asymmetric Double Functional Group PEGs (R₁-PEG-R₂)

R1:	H-；NH₂-；COOH-；MAL-；ACLT-；Biotin-；Gluc-；Gala-；AC-；BOC-；NH-；DSPE-；Fluorescein-；OPSS-；Thiol-；ACRL-；FMOC-NH-；
R2:	-NH₂；-CH₂NH₂；-CH₂CH₂CH₂NH₂；-COOH；-CH₂CH₂COOH；-CHO；-CH(OEt)₂_；-NHS；-MAL；SCM；-SC；-Biotin；-Acid；-CM；-SVA；-VA；-Silane；

3、Symmetry Double Functional Group PEGs (R-PEG-R)

R:	NH₂；CH₂NH₂；CH₂CH₂COOH；EP-MAL；PP-MAL；NHS；OPSS；AC；ALD；Azide；；EP；GA；Hydrazide；NPC；SH；ACRL；-ButyrALD；-Thiol； Tosylate；VA；

4、Multi-arm Branched PEGs (PEG_n-R(n=2、3、4))

R:	-TS；-NP；-GS2；-MAL（C2、C5）；-ALD；-PA；CA；-COO-NHS;-CH₂CH₂CH₂-NHCO-(CH₂)₃-COO-NHS

5、Lysine Branched PEGs

X:	-O-NHS; -NH-CH₂CH₂-CHO; -NH(CH₂)₂-NHCO-(CH₂)-maleimide

6、Forked PEGs

X:	-CH₂CH₂-NHCO-(CH₂)₃-COO-NHS; -CH₂ CH₂NH₂;--CH₂CH₂-NHCO-(CH₂)_2-maleimide

7、Released PEGs (mPEG-(CH₂)n-Y-linker-X)

X:	-TS；
Y:	-COO-C₆H₅-;-COO-C₆H₃(CH₃)₂

8、Multi-arm PEGs (PEG-X)_n（n=3、4、6、8）

X:	-CO-CH₂CH₂-COO-NHS; -CO-CH₂CH₂CH₂-COO-NHS; -CH₂CH₂CH₂CH₂-COO-NHS; -CH₂CH₂CH₂NH₂; -CH₂CH₂NH₂; -CH₂CH₂SH; -(CH₂)₃-NHCO-CH₂CH₂-Maleimide; -COO-phenyl-NO₂

9、Copolymers

A-b-PEG	A：PS；PI；PAN；PCL；PMMA；PPO；PGLY；PECH
mPEG-b-A	A：PS；PI；PAN；PCL；PMMA；PPO；PGLY；PECH
A-b-PEG-b-A	A：PHB； PHB/V；PCL；PLA
R1-(PEG-b-A)-R2	A：PS；PI；PAN；PCL；PMMA；PPO；PGLY；PECH R1：Br；R2：OH
R1-(A-b-PEG)-R2	A：PHB；PHB/V；PCL；PLA；PPO；PGLY；PECH R1：Br；R2：OH
R-(PEG-b-A-b-PEG)-R	A：PPO；PGLY；PECH R：OH
(PEG-b-A)-R	A：PS；PI R：OH
R-(PEG-b-A-b-PEG)	A：PS；PI R：OH
A-b-(PEG)2	A：PS；PI

Seebio Biotech, Inc.
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Shanghai 201204, P.R.China
Tel: 86-21-50272981
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