化学名称：Dextran, hydrogen sulfate sodium salt; Dextran sulphate; Sodium dextran sulfate; Dextran polysulfate
CAS 编号：9011-18-1

硫酸葡聚糖是由特定分子量的葡聚糖硫酸化反应制得的。TdB生产的低取代度硫酸葡聚糖分子量从5 kDa到500 kDa。

硫酸葡聚糖是以钠盐形式呈现，并加入少量磷酸盐作为稳定剂。 每个批次的产品都提供质检报告COA。严格仔细控制分子量程，含硫量，湿度等指标。

葡聚糖是一种多糖，来源于肠系膜明串珠菌B512F，由α-D-(1-6)线性葡聚糖组成，侧链含量较低（约5%），与葡萄糖的碳-3位相连。硫酸葡聚糖是特定分子量的葡聚糖硫酸化得到的衍生物。低取代度硫酸葡聚糖的硫酸组分在8-13%之间。

图1。低取代度硫酸葡聚糖片段的结构表征。

硫酸葡聚糖（DS）可按不同平均重均分子量，不同分子量分布，不同程度的取代度，不同阳离子（例如钾替代钠）和不同硫酸化过程来生产。例如，仅凭硫酸葡聚糖70的名称无法完整识别该化合物，在评估这些化合物性能时应考虑到这一点。

硫酸葡聚糖是由选定的葡聚糖片段和硫酸化试剂（例如氯磺酸）合成而来，反应混合物经过纯化后，可以获得白色粉末状产品。

室温下，硫酸葡聚糖在干燥密闭的容器内可以保持稳定超过6年。

硫酸葡聚糖涉及非常广泛的应用领域和性质。举例如下

• 细胞培养用的抗凝剂
• 脂蛋白的选择性淀析
• 加速DNA杂交
• 从DNA-组蛋白复合物中释放DNA
• 抑制tRNA与核糖体的结合
• 核糖核酸酶抑制剂
• 抗病毒性
• 用于化妆品的抗感染和透水保湿
• 分离微生物和大分子
• 疫苗佐剂
• 膜选择性渗透研究

产品编号	品名	分子量(kDa)	包装
DB005-10g	Dextran sulfate 5 LS	5	10 g
DB005-100g			100 g
DB009-10g	Dextran sulfate 10 LS	10	10 g
DB009-100g			100 g
DB013-10g	Dextran sulfate 20 LS	20	10 g
DB013-100g			100 g
DB003-10g	Dextran sulfate 40 LS	40	10 g
DB003-100g			100 g
DB015-10g	Dextran sulfate 100 LS	100	10 g
DB015-100g			100 g
DB051-10g	Dextran sulfate 500 LS	500	10 g
DB051-100g			100 g

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Persson, B., Hugerth, A., Caram-Lelham, N. & Sundelöf, L.-O. Dextran Sulfate−Amphiphile Interaction; Effect of Polyelectrolyte Charge Density and Amphiphile Hydrophobicity. Langmuir 16, 313–317 (2000).

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Vyas, S. V., Burne, M. J., Pratt, L. M. & Comper, W. D. Glomerular Processing of Dextran Sulfate during Transcapillary Transport. Archives of Biochemistry and Biophysics 332, 205–212 (1996).

Wells, X. E. & Dawes, J. Role of the Liver and Kidney in the Desulphation of Heparin in vivo. Thromb Haemost 74, 667–672 (1995).

Vyas, S. V., Parker, J.-A. & Comper, W. D. Uptake of dextran sulphate by glomerular intracellular vesicles during kidney ultrafiltration. Kidney International 47, 945–950 (1995).

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