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【新品发布】糖尿病领域新秀—Exendin-4 酶免试剂盒全新上市

来源:作者:人气:-发表时间:2019-05-20 16:07:00【
Exendin-4由39个氨基酸残基组成,与胰高血糖素样肽1(GLP-1)有53%的同源性,是GLP-1受体激动剂,与GLP-1类似, Exendin-4 可调节血糖浓度,但GLP-1的半衰期仅有2min,而Exendin-4半衰期却长达9.57h,因此在治疗2型糖尿病方面具有广阔的前景。
Exendin-4具有促进胰腺胰岛素的分泌、增加胰岛素敏感性及改善胰岛细胞功能的作用,且不被二肽基肽酶Ⅳ(DPP-Ⅳ)分解,血浆半衰期较长,因而在人类,对糖尿病治疗应用来说是稳定、长效的有治疗前景的药物。Exendin-4的相关研究以及药物开发越来越受到业内人士的关注,西宝生物可提供用于相关药物研发生产的Phoenix Pharmaceuticals品牌Exendin-4 (Heloderma suspectum) EIA Kit用于EIA酶免疫实验,用于实验室快速检测艾塞那肽。订购咨询热线:400-021-8158
Phoenix Pharmaceuticals品牌
主要从事小分子活性多肽生物学效应和临床免疫定量分析技术和服务,从事肥胖相关肽、心血管活性肽的药理学应用性研究和临床标示物筛选以及应用,产品线包括:多肽和多肽药物合成、多肽标记、抗体和多肽免疫试剂盒,目前已开发和销售产品达8000多种,主要服务于药厂和生命科技研究中心、医学和生物科技研究机构。包括辉瑞(Pfizer)、葛兰素史克(GlaxoSmithKline)、赛诺菲-安万特(sanofi-aventis)、诺华(Novartis)及强生(Johnson & Johnson)等知名制药企业。
1 产品订购信息:
产品货号
产品名称
规格
报价(元)
研究领域
EK-070-94
Exendin-4 (Heloderma suspectum) - EIA Kit
艾塞那肽 酶免疫试剂盒
96 Wells
7185.00
糖尿病
2 试剂盒Kit详情:
1. EIA assay buffer concentrate (20x, 50ml) 20×检测缓冲浓缩液
2. Pre-coated EIA plate (96 wells, 1 plate)96孔酶标版
3. Acetate plate sealer (APS) (3 pieces) APS封板膜
4. Primary antibody (1 vial) Exendin-4一抗
5. Standard peptide (1 vial) Exendin-4肽标准品
6. Biotinylated peptide (1 vial) 生物素标记肽
7. Positive control (2 vials) 阳性对照质控
8. Streptavidin-horseradish peroxidase (SA-HRP)concentrate (30μl) 辣根过氧化物酶-链霉亲和素
9. Substrate solution (12ml) TMB显色液
10. 2N HCl (Stop solution) (15ml) 终止液
3 试剂盒介绍:
1.样品提取:重组
2.灵敏度:0.08 ng/ml
3.线性测量范围: 0.08 - 0.86 ng/ml
4.批内差异:<10%
5.批间差异:<15%
6.交叉反应:
Peptide
%
 Exendin-4 (Heloderma Suspectum)
100
 Exendin-3 (9-39)-NH2
100
 Exendin-4 (3-39)
100
 Lixisenatide
100
 Glucagon (Human, Rat, Mouse, Porcine, Bovine)
0
 GLP-1 (7-36)-NH2 (Human, Rat, Mouse)
0
 GLP-1 (7-37) (Human, Rat, Mouse)
0
 GLP-2 (Human)
0
 Oxyntomodulin (Human, Rat, Mouse)
0
7.标准曲线:
4 注意事项:
1.试剂盒存放在4℃下有效期24个月
2.试剂盒中的试剂复溶以后尽快使用完毕,避免隔夜放置
3.条件允许的情况下请把 EIA assay buffer存放在4℃下
4.条件允许的情况下把试剂盒中的生物肽 缓冲液 抗体 链酶核素辣根过氧化物酶等产品存放在4℃
5..未使用的板条请储存在铝箔封闭袋中,至于4℃冰箱中,避免有其他水分进入。
5 相关产品:
产品货号
产品名称
规格
报价(元)
RK-APRO
Aprotinin, 30 Trypsin Inhibitory Units (TIU)
5 ml
1380.00
VT-6450
Lavender Vacutainer Tubes
100 tubes
1140.00
EK-BUF
Assay Buffer (20x Concentrate) for EIA/ELISA
50 ml
795.00
RK-BA-1
Buffer A
1x 500 ml
450.00
RK-BB-1
Buffer B
1x 100 ml
540.00
RK-SEPCOL-1
C-18 SEP-Column Pack
50 columns
2400.00
RK-EXTRACT
Extraction Kit Set (2 Buffer A, 2 Buffer B and 1 SEP-Column)
1 Set
4260.00 

6 周边产品:
产品货号
产品名称
规格
报价(元)
RKU-070-94
Exendin-4 (Heloderma suspectum) - Ultra-Sensitive RIA Kit
125 tubes
9135.00
CEK-070-94
Exendin-4 - Chemiluminescent EIA Kit
96 Wells
7770.00
RK-070-94
Exendin-4 (Heloderma suspectum) - RIA Kit
125 tubes
9135.00
FEK-070-94
Exendin-4 (Heloderma Suspectum) - Fluorescent EIA Kit
96 Wells
7770.00
EK-070-94
Exendin-4 (Heloderma suspectum) - EIA Kit
96 Wells
7185.00
070-94
Exendin-4 (Heloderma suspectum)
100 µg
2220.00
028-20
Exendin-4 [Tyr0, Ser2] (1-9)
100 µg
2070.00
070-99
Exendin-4 (3-39) (Heloderma suspectum) / P1, Inhibitor of Platelet Calpain
100 µg
2070.00
070-92
Exendin-3 (Heloderma horridum)
100 µg
2220.00
028-18
Exendin-4 (1-9), Ser2
100 µg
1500.00
071-26
Exendin-3 (9-39) [Tyr0]
100 µg
2070.00
070-93
Exendin-3 (9-39)-Amide (Heloderma Horridum)
100 µg
1665.00
T-G-070-94
Exendin-4 (Heloderma suspectum) - I-125 Labeled Purified IgG
10 µCi
11235.00
FR-G-070-94
Exendin-4 (Heloderma suspectum) - Rhodamine Labeled Purified IgG
100 µl
7920.00
FC3-G-070-94
Exendin-4 (Heloderma suspectum) - Cy3 Labeled Purified IgG
100 µl
8700.00
FG-G-070-94A
Exendin-4 - FAM Labeled Purified IgG
100 µl
7920.00
B-G-070-94
Exendin-4 (Heloderma suspectum) - Biotin Labeled Purified IgG
100 µl
7920.00
H-070-94
Exendin-4 (Heloderma suspectum) - Antibody for Immunohistochemistry
100 µl
7125.00
G-070-94
Exendin-4 (Heloderma suspectum) - Purified IgG Antibody
200 µg
7125.00
FG-070-94A
Exendin-4 (Heloderma suspectum) - FAM labeled
1 nmol
5535.00
T-071-26
Exendin-3 (9-39) [Tyr0] - I-125 Labeled
10 µCi
11235.00
T-070-94
Exendin-4 (Heloderma suspectum) - I-125 Labeled
10 µCi
9750.00
B-070-99
Exendin-4 (3-39) [Biotinyl] (Heloderma suspectum) - Biotin Labeled
100 µg
5535.00
FG-070-93A
Exendin-3 (9-39)-Amide (Heloderma horridum) - FAM Labeled
1 nmol
3165.00
FG-070-92A
Exendin-3 (Heloderma horridum) - FAM Labeled
1 nmol
3165.00
FEK-070-94CE
Exendin-4 (Heloderma suspectum) - Fluorescent EIA Kit, CE Mark Certified
96 wells
8085.00 
7 参考文献:
Pyung-Hwan Kim, Minhyung Lee, Sung Wan Kim, Delivery of two-step transcription amplification exendin-4 plasmid system with arginine-grafted bioreducible polymer in type 2 diabetes animal model. J Control Release. 2012 Aug 20;162(1):9-18. doi: 10.1016/j.jconrel.2012.06.010. Epub 2012 Jun 15.
Di pasquale G, Dicembrini I, Raimondi L, et al. Sustained exendin-4 secretion through gene therapy targeting salivary glands in two different rodent models of obesity/type 2 diabetes. PLoS ONE. 2012;7(7):e40074.
Nian Gong et al., Site-specific PEGylation of exenatide analogues markedly improved their glucoregulatory activity Br J Pharmacol. 2011 May; 163(2): 399–412. 
Wei Gao et al., Pharmacokinetic and Pharmacodynamic Modeling of Exendin-4 in Type 2 Diabetic Goto-Kakizaki Rats J Pharmacol Exp Ther. 2011 March; 336(3): 881–890. doi:  10.1124/jpet.110.175752
Su Young Chaea, Cheng-Hao Jin et al., Biochemical, pharmaceutical and therapeutic properties of long-acting lithocholic acid derivatized exendin-4 analogs Journal of Controlled Release Volume 142, Issue 2, 3 March 2010, Pages 206–213  
Kamei et al. Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides.J Control Release. 2009 Feb 27. [Epub ahead of print]
Samson et al. Gene therapy for diabetes: metabolic effects of helper-dependent adenoviral exendin 4 expression in a diet-induced obesity mouse model. Mol Ther. 2008 Nov;16(11):1805-12.  
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