研究生物技术药物的免疫毒性ELISA试剂盒

来源：seebio.cn作者：西宝生物人气：-发表时间：2013-08-28 14:28:00【大中小】

研究生物技术药物的免疫毒性ELISA试剂盒

抗-KLH，抗-SRBC，抗-破伤风类毒素，抗-DNP和抗-TNP IgM和IgG被用作免疫毒性的生物标志物。西宝生物供应美国进口检测小鼠，大鼠，鸡和猴中这些重要生物标志物的ELISA试剂盒。在临床前研究中，使用免疫原比如KLH免疫用过药物的动物。收集第7天或21天的血清，检测抗-KLH IgM和IgG，与没有用药的对照组进行比较。用过药的抗-KLH水平降低，提供了免疫抑制的证据。

相关ELISA试剂盒产品：

Anti-KLH IgG & IgM ELISA Kits （抗-KLH IgG & IgM ELISA试剂盒）
ELISA Kit (1 x 96-well)	中文名称	产品编号	规格
Mouse Anti-KLH IgM	小鼠抗-KLH IgM	ADM0769A	1 Kit
Mouse Anti-KLH IgG	小鼠抗-KLH IgG	ADM0770A	1 Kit
Rat Anti-KLH IgM	大鼠抗-KLH IgM	ADM0771A	1 Kit
Rat Anti-KLH IgM with Controls	大鼠抗-KLH IgM，带对照	ADM0772A	1 Kit
Rat Anti-KLH IgG	大鼠抗-KLH IgG	ADM0773A	1 Kit
Rat Anti-KLH IgG with Controls	大鼠抗-KLH IgG,带对照	ADM0774A	1 Kit
Guinea Pig Anti-KLH IgG	豚鼠抗-KLH IgG	ADM0775A	1 Kit
Monkey Anti-KLH IgM (ng/ml)	猴抗-KLH IgM	ADM0777A	1 Kit
Monkey Anti-KLH IgG (ng/ml)	猴抗-KLH IgG	ADM0779A	1 Kit
Anti-Sheep Red Blood Cell IgG & IgM ELISA Kits
ELISA Kit (1 x 96-well)	中文名称	产品编号	规格
Mouse Anti-SRBC IgM	小鼠抗-SRBC IgM	ADM0780A	1 Kit
Mouse Anti-SRBC IgG	小鼠抗-SRBC IgG	ADM0781A	1 Kit
Rat Anti-SRBC IgM	大鼠抗-SRBC IgM	ADM0782A	1 Kit
Rat Anti-SRBC IgG	大鼠抗-SRBC IgG	ADM0783A	1 Kit
Chicken Anti-SRBC IgM	鸡抗-SRBC IgM	ADM0784A	1 Kit
Chicken Anti-SRBC IgG	鸡抗-SRBC IgG	ADM0785A	1 Kit

Anti-Tetanus Toxoid IgG & IgM ELISA Kits
ELISA Kit (1 x 96-well)	中文名称	产品编号	规格
Rat Anti-Tetanus Toxoid IgM	大鼠抗-破伤风类毒素IgM	ADM0786A	1 Kit
Rat Anti-Tetanus Toxoid IgG	大鼠抗-破伤风类毒素IgG	ADM0787A	1 Kit
Monkey Anti-Tetanus Toxoid IgM (ng/ml)	猴抗-破伤风类毒素IgM	ADM0788A	1 Kit
Monkey Anti-Tetanus Toxoid IgG1 (ug/ml)	猴抗-破伤风类毒素IgG1	ADM0789A	1 Kit

Anti-DNP IgG & IgM ELISA Kits
ELISA Kit (1 x 96-well)	中文名称	产品编号	规格
Mouse Anti-DNP IgG	小鼠抗-DNP IgG	ADM0790A	1 Kit
Mouse Anti-DNP IgM	小鼠抗-DNP IgM	ADM0791A	1 Kit
Rat Anti-DNP IgG	大鼠抗-DNP IgG	ADM0792A	1 Kit
Rat Anti-DNP IgM	大鼠抗-DNP IgM	ADM0793A	1 Kit

Anti-TNP IgG & IgM ELISA Kits
Mouse Anti-TNP IgM	小鼠抗-TNP IgM		1 Kit

大鼠和猴抗-KLH IgG ELISA试剂盒已获得评估，并且在一些著名的实验室获得了认可（确认ELISA试剂盒可用于大鼠和猴血清中抗-KLH IgG的定量分析）CIT, Evreux, France. Armelle N. Guyen, Sandrine Arthaud, Phillipe Ancian and Roy Forster. Toxicology Letters, Volume 180, Supplement 1, 5 October 2008, Page S211).

应用声明：所有产品仅用于科研，不能应用于诊断和治疗。

引用试剂盒产品相关文献：

Guyen AN, Arthaud S, Ancian P and Foster R. Validation of an ELISA assay for quantification of anti-KLH IgG in rat and monkey sera. Toxicology Letters (Abstracts) 180S: S211/I11 (2008)
Betz BC,Jordan-Williams KL, Wang C, Kang SG, Liao J, Logan MR, Kim CH and Taparowsky EJ. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J. Exp. Med. 207(5):933-942 (2011) [Mouse anti-SRBC IgG & IgM] http://jem.rupress.org/content/207/5/933.full.pdf+html
Schaffer BS, Grayson MH and Wortham JM, et al. Immune competency of a hairless mouse strain for improved preclinical studies in genetically engineered mice. Mol. Cancer Ther. 9:2354-2364 (2010) [Mouse anti-KLH IgG & IgM] http://mct.aacrjournals.org/content/9/8/2354.full.pdf+html
Efanov A, Zanesi N, NazaryanN, Santanam U, Palmarchuck A Croce CM and Pekarsky Y. CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. Leukemia 24:970-975 (2010) [Mouse anti-SRBC IgM]
Nain S and Smits JEG. Pathological, immunological and biochemical markers of subchronic arsenic toxicity in rats. Environmental Toxicology. (2010) http://onlinelibrary.wiley.com/doi/10.1002/tox.20635/abstract [Rat anti-KLH IgG & IgM]
Zhou X, Xiang Y, Ding, X and Garrard WT. Anew hypersensitive site, HS10, and the enhancers, E3′ and Ed, differentially regulate Igk gene expression. J. Immunol. 188:2722-2732 (2012) [Mouse anti-KLH IgG & IgM]
Sah S and Smits J. Dietary selenium fortification: a potential solution to chronic arsenic toxicity. Toxicological & Environmental Chemistry. 94(7): 1453-1465 (2012) [Rat anti-KLH IgG]
Anderson SE, Franko J, Anderson KL, Munson AE, Lukomska E, Meade BJ. Immunotoxicity and allergic potential induced by topical application of dimethyl carbonate (DMC) in a murine model. J Immunotoxicol. [Epub ahead of print] (2012) [Mouse anti-SRBC IgM]
Aulí M, et al. Multiparametric immunotoxicity screening in mice during early drug development. Toxicol Lett. [Epub ahead of print] (2012) [Mouse anti-KLH IgM]
Sah S and Smits J. Treating chronic arsenic toxicity with high selenium lentil diets. Toxicol Appl Pharmacol. doi: 10.1016/j.taap.2013.06.008. (2013) [Rat anti-KLH IgG]