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Cell子刊:独特的机制保护胰腺细胞免受炎症的影响
科隆大学的研究人员揭示了一种保护胰腺β细胞的机制,这种细胞对胰岛素的产生至关重要,可以防止炎症细胞死亡。本研究探讨受体相互作用蛋白激酶1 (receptor-interacting protein kinase 1, RIPK1)在调节β细胞存活中的作用。[查看]
http://www.cxbio.com/Article/cellzkdtdjzbhyxxbmsy_1.html
P<font color='red'>NAS</font>:影响肠道微生物群健康和对细菌感染反应的蛋白质
摘要:根据发表在PNAS上的一篇文章,不产生白细胞介素22结合蛋白(IL-22BP)的小鼠具有更强的防御能力。 发表在《美国国家科学院院刊》(PNAS)上的一项研究表明,一种名为IL-22BP的特定蛋白质的存在如何影响肠道微生物群的组成和身体对细菌感染的反应。 “我们发现,不产生这种蛋白质的小鼠更能抵御艰难梭状芽孢杆菌和啮齿柠檬酸杆菌等细菌的肠道感染,”该文章的合著者Marco aur lio Ramirez Vinolo告诉记者。他是巴西坎皮纳斯州立大学生物研究所(IB-UNIC[查看]
http://www.cxbio.com/Article/pnasyxcdwswqjkhdxjgr_1.html
VLVbio 细胞凋亡坏死检测试剂盒
VLVbio,专注于研究检测细胞死亡方式(凋亡或坏死),可提供M30 Apoptosense? ELISA试剂盒和M65 EpiDeath? ELISA试剂盒,广泛用于非酒精性脂肪性肝炎(NASH) 的研究和药物开发领域。[查看]
http://www.cxbio.com/Article/VLVbio_1.html
<font color='red'>NAS</font>H生物标记物检测试剂盒
M30 Apoptosense(R) ELISA可检测 K18 片段的浓度,是检测和筛查 NASH 的可靠的特异性工具。最近的两项荟萃分析表明,K18 片段的水平可以预测 NASH 的存在,其 pooled AUROC 值为 0.82、伴随 78% 的灵敏度和 86% 的特异性;AUROC 值为 0.8445、伴随 83% 的灵敏度和 71% 的特异性。[查看]
http://www.cxbio.com/Article/M30_1.html
<font color='red'>NAS</font>H细胞核受体
了解核受体如何参与非酒精性脂肪性肝病(NAFLD)或非酒精性脂肪性肝炎(NASH)的发病机制,可能为肝病新疗法的研发提供新的方向。在药物和治疗发现中,最常见的核受体是由配体激活的核受体,包括过氧化物酶体增殖物激活受体α(PPARα)、孕烷X受体(PXR)和组成型雄甾烷受体(CAR),它们是最早被确定的化学毒物反应的关键调节受体。使用小鼠疾病模型和人体样本的大量研究表明,这些受体和PPARβ/δ、PPARγ、法尼醇X受体(FXR)和肝X受体(LXR)等其他受体,通过调节肠-肝-脂肪轴在维持营养/能量稳态方面发挥着关键作用。[查看]
http://www.cxbio.com/Article/NASH_1.html
P<font color='red'>NAS</font>:大肠杆菌如何造成尿路感染
近日,一项发表在《美国国家科学院院刊》(PNAS)上的研究分析了大肠杆菌(E. coli)如何在几乎无菌的新鲜尿液中利用宿主的营养物质快速繁殖。[查看]
http://www.cxbio.com/Article/pnasdcgjrhzcnlgr_1.html
胶原酶,纯化/ Collagenase, Purified
低蛋白酶活性的胶原酶,为色谱纯化的胶原酶。与天然的胶原酶相比,其蛋白酶活性更低,与其他蛋白酶结合可用于细胞分散。除了胰脏、腮腺腺泡分散外,还可用于分析胶原的构造。[查看]
http://www.cxbio.com/Article/Collagenase_1.html
《P<font color='red'>NAS</font>》肺部隐藏的抗流感大军
发表在《PNAS》上的一篇论文详细介绍了在流感感染期间,巨噬细胞如何离开外腔进入肺部,在那里它们减少炎症和降低疾病水平。[查看]
http://www.cxbio.com/Article/pnasfbycdklgdj_1.html
P<font color='red'>NAS</font>:新技术让癌细胞更容易暴露出来
日本北海道大学和美国密苏里大学等机构的研究人员开发出一种新技术,以增加癌细胞中MHC I类分子的数量。据介绍,这种新方法有望增强免疫系统检测和消除癌细胞的能力。[查看]
http://www.cxbio.com/Article/pnasxjsraxbgryblcl_1.html
《P<font color='red'>NAS</font>》一种不为人知的蛋白质,它能保持人体细胞的健康
圣保罗大学的研究人员与澳大利亚同事合作,发现了一种独特的细菌蛋白,即使细胞有沉重的细菌负担,也能保持人体细胞的健康。这一突破为开发与线粒体功能障碍相关的各种疾病(包括癌症和自身免疫性疾病)的新疗法提供了潜力。线粒体是细胞的“发电站”,对提供细胞生化反应所需的能量至关重要。[查看]
http://www.cxbio.com/Article/20240130_industrialnews_1.html
《Cell》身体发炎,究竟是谁负责精准地招募中性粒细胞?
新的研究表明,细胞表面RNA是中性粒细胞募集到炎症部位的关键。这些中性粒细胞细胞表面的“糖RNA”促进与内皮细胞的结合和跨内皮细胞的迁移。结合先前的研究表明,glycoRNAs可以在许多细胞类型中发现,glycoRNAs可能在多种细胞类型和多种生物环境中发挥重要功能。[查看]
http://www.cxbio.com/Article/20240124_industrialnews_1.html
P<font color='red'>NAS</font>:脂肪酸调节脂质生物合成的新途径
在最近的一项研究中,筑波大学的一组研究人员发现了一种新的SREBP-1c裂解酶,SREBP-1c是脂肪酸生物合成的关键角色。此外,该团队首次揭示了肝脏中脂肪酸的生物合成过程是由饱和脂肪酸激活的,而由多不饱和脂肪酸抑制的[查看]
http://www.cxbio.com/Article/pnaszfsdjzzswhcdxtj_1.html
P<font color='red'>NAS</font>:一种新的检测方法有望早期发现帕金森病
布里格姆妇女医院的研究人员,麻省总医院布里格姆的创始成员,和哈佛大学Wyss生物启发工程研究所开发了一种分子分析平台,他们成功地应用于患者样本,以检测和量化单个synuclein原纤维,synuclein的致病聚集体是PD和其他神经退行性疾病的标志,被称为synucleinopathies。他们的研究结果发表在《美国科学院院刊》上。[查看]
http://www.cxbio.com/Article/pnasyzxdjcffywzqfxpj_1.html
《P<font color='red'>NAS</font>》合成酶来解开分子之谜
克萨斯大学达拉斯分校的一位生物工程师开发出了一种合成酶,可以控制信号蛋白Vg1的行为,Vg1在脊椎动物胚胎的肌肉、骨骼和血液的发育中起着关键作用。[查看]
http://www.cxbio.com/Article/pnashcmljkfzzm_1.html
P<font color='red'>NAS</font>:活性酶的图像揭示了耐抗生素细菌的秘密
先进的显微镜技术为科学家们提供了有价值的线索,让他们知道如何对抗一种导致全球抗生素耐药性细菌感染病例增加的核糖体修饰酶。[查看]
http://www.cxbio.com/Article/pnashxmdtxjslnkssxjd_1.html
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