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P<font color='red'>NAS</font>:研究揭示大脑与肠道之间的联系
在最近一项研究中,匹兹堡大学脑研究所的神经科学家已经找到了将大脑连接到胃的神经通路,从而提供了一种生物学机制来解释压力如何促进溃疡的发展。[查看]
http://www.cxbio.com/Article/pnasyjjsdnycdzjdlx_1.html
P<font color='red'>NAS</font>:揭示SARS-CoV-2高传染性和隐蔽性的原因!
导致COVID-19的SARS-CoV-2病毒具有高度传染性。奇怪的是,在许多病人中,它会引起较差的免疫反应,从而延长疾病的时间。这有助于病毒的广泛传播,加剧了全球大流行。在发表在Proceedings of the National Academy of Sciences杂志上的一项新研究中,明尼苏达大学的研究人员发现了一种生物化学机制,这种机制或许可以解释这种病毒如何在有效感染人类的同时逃避免疫反应。[查看]
http://www.cxbio.com/Article/pnasjssarscov2gcrxhy_1.html
P<font color='red'>NAS</font>重大突破:发现抗衰老的关键生化机制
衰老是生命中不可避免的一部分,但有些物种衰老的方式与其他物种非常不同,甚至与非常相似的物种也不一样。例如,一种体型与鼹鼠或老鼠相仿的东非啮齿动物--裸鼹鼠,表现出明显的延缓衰老过程,可活到30岁。来自俄罗斯、德国和瑞士的科学家现在在老鼠,蝙蝠和裸鼢鼠细胞中证实了一种和衰老相关的机制--一个线粒体内膜"轻度的去极化"过程:轻度去极化调节细胞中线粒体活性氧的产生(mROS),因此是一种抗衰老的机制。在小鼠中,这种机制在1岁时瓦解,而在裸鼹鼠中直到20岁才开始瓦解。近日发表在《PNAS》上的这篇论文详细描述了这一新证实的机制。[查看]
http://www.cxbio.com/Article/pnaszdtpfxksldgjshjz_1.html
P<font color='red'>NAS</font>:科学家有望开发出治疗艰难梭菌感染的新型药物疗法
近日,一项刊登在国际杂志Proceedings of the National Academy of Sciences上的研究报告中,来自纽约市立大学等机构的科学家们通过研究或有望帮助开发治疗艰难梭菌(clostridium difficile)感染的新药,艰难梭菌会引发腹泻、恶心、内出血和潜在死亡,其对公众健康会带来严重威胁,每年在美国这种细菌都会感染大约50万人,而且会造成1.5万人死亡。[查看]
http://www.cxbio.com/Article/pnaskxjywkfczljnsjgr_1.html
P<font color='red'>NAS</font>:揭示机体免疫系统抵御沙门氏菌感染的分子机制
日前,一项刊登在国际杂志PNAS上的研究报告中,来自东英吉利亚大学的科学家们通过研究揭示了人类机体应对沙门氏菌感染的分子机制,文章中,研究人员阐明了,血液干细胞如何通过获取来自骨髓支持细胞的能量在感染的最初几个小时内产生反应,本文研究结果或能帮助研究者开发新型疗法来治疗沙门氏菌的感染和其它细菌性疾病。[查看]
http://www.cxbio.com/Article/pnasjsjtmyxtdysmsjgr_1.html
Science子刊:Lrrk2等位基因在小鼠的微生物感染过程中以性别依赖的方式调节炎症
富含亮氨酸的重复激酶-2 (leucine-rich repeat kinase-2,LRRK2)基因的变异与帕金森病、麻风病和克罗恩病(以炎症为重要组成部分的三种疾病)有关。LRRK2在粒细胞和CD68阳性细胞中高表达,可能具有先天免疫功能。[查看]
http://www.cxbio.com/Article/sciencezklrrk2dwjyzx_1.html
【新品速递】Cisbio 药物靶标胞外激酶(Kinase)活性检测整体解决方案
为了支持激酶类药物的筛选、发现与开发,西宝生物携手Cisbio为您提供多种激酶类型,从检测方法优选、高通量筛选到选择性分析等一系列激酶研究解决方案。Cisbio 激酶检测,是基于抗体的检测产物生成的解决方案,其特异性各不相同。包括基于 ADP 定 量的适用于所有激酶的 ADP Transcreener 检测试剂盒;利用通用底物的经过两百多种激酶验证 的 KinEASE 试剂盒;利用特定底物、特异抗体的 HTRF 工具箱解决方案。[查看]
http://www.cxbio.com/Article/cisbiobnjmhxjcztjjfa_1.html
年轻血液中的突触增强因子有望让年老小鼠返老还童
在一项新的研究中,来自美国斯坦福大学的研究人员在年轻小鼠的血液中发现突触增强因子。相关研究结果近期发表在PNAS期刊上。在这篇论文中,他们研究了来自年轻小鼠的血液在被注入到年老小鼠体内时所产生的恢复青春的效果,以及他们从中学到的知识。[查看]
http://www.cxbio.com/Article/nqxyzdtczqyzywrnlxsf_1.html
为什么老是过敏?可能是肠道微生物在作怪
过去几年来,科学家们已经发现了肠道微生物紊乱和不同疾病之间存在联系。而现在在一项最新研究中,来自法国国家科学研究院(CNRS)、法国国家健康与医学研究院(INSERM)和法国里昂第一大学及美国NIH的研究人员一起发现一种病毒检测系统、肠道微生物组成和皮肤过敏之间的关系。他们的发现于近日发表在《PNAS》上,可能带来潜在的皮肤过敏新疗法。[查看]
http://www.cxbio.com/Article/wsmlsgmknscdwswzzg_1.html
从检验医学角度出发,中国专家液体活检研究脱颖而出
4月15日,美国癌症研究协会(AmericanAssociation for Cancer Research,AACR)2018年年会上,由上海市胸科医院娄加陶主任主持的肺癌EGFR/KRAS/BRAF ctDNA-NGS多中心性能验证项目,经过AACR专家委员会层层甄选后,成为液态活检分论坛(mini symposium: liquid biopsy1)上分享的唯一一个以中国专家为主导的科研项目。[查看]
http://www.cxbio.com/Article/cjyyxjdcfzgzjythjyjt_1.html
P<font color='red'>NAS</font>:将人血液中的T细胞直接转化为功能性神经元,转化效率高达6.2%
在一项新的研究中,来自美国斯坦福大学医学院的研究人员发现在仅加入4种蛋白大约3周内,就能够在实验室中将人血液中的免疫细胞直接转化为功能性的神经元。这种显著的转化并不需要这些免疫细胞首先进入一种被称作多能性的状态,相反是通过一种更加直接的被称作转分化的过程发生的。[查看]
http://www.cxbio.com/Article/pnasjrxyzdtxbzjzhwgn_1.html
癌症免疫疗法系统如何实现远程控制?
来自加州大学圣地亚哥分校的研究小组开发出了一种基于超声波的系统,它可以对活的免疫T细胞进行非侵入性和远程控制,使它能够识别并杀死癌细胞。研究发表在《PNAS》上。[查看]
http://www.cxbio.com/Article/azmylfxtrhsxyckz_1.html
Nucleic Acids Research:研究发现线粒体翻译质量控制对于胚胎发育的重要性
近日,中国科学院上海生命科学研究院生物化学与细胞生物学研究所王恩多研究组,与芬兰科学家合作的最新研究成果,以Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria为题,发表在《核酸研究》(Nucleic Acids Research)上。哺乳动物细胞含有两个相对独立的翻译系统:细胞质和线粒体翻译系统。[查看]
http://www.cxbio.com/Article/nucleicacidsresearch_1.html
P<font color='red'>NAS</font>:如何让小鼠吃的更少?
最近,来自纽约州立大学的研究者们发现,通过人为刺激小鼠大脑中隔复合体(medial septal complex)中的神经元,能够导致小鼠食欲的下降,相关结果发表在《PNAS》杂志上。[查看]
http://www.cxbio.com/Article/pnasrhrxscdgs_1.html
P<font color='red'>NAS</font>:重磅!科学家在细菌基因组中发现抗癌药物的“蓝图”
近日,一篇刊登在国际杂志Proceedings of the National Academy of Sciences上的研究报告中,来自美国斯克里普斯研究所(The Scripps Research Institute)的研究人员通过研究表示,他们此前发现能够杀灭前列腺癌细胞的化合物LNM E1或许能通过通过“挖掘”储存在细菌基因组中的信息,促进LNM分子家族更接近于研究人员进行相关的临床试验,相关研究表明,隐藏的基因或许能帮助科学家们开发新型有效的靶向抗癌化合物。[查看]
http://www.cxbio.com/Article/pnaszbkxjzxjjyzzfxka_1.html
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Proteinase K
Proteinase K
Glycerol Kinase Amano2
Glycerol Kinase Amano2
Cholesterol Dehydrogenase Amano 5
Cholesterol Dehydrogenase Amano 5
Glucose Dehydrogenase Amano 2
Glucose Dehydrogenase Amano 2
Lactate Dehydrogenase Amano 3
Lactate Dehydrogenase Amano 3
Malate Dehydrogenase Amano 3
Malate Dehydrogenase Amano 3
Penicillinase
Penicillinase
Penicillinase Bulk Powder
Penicillinase Bulk Powder
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade I,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactate oxidase), Grade II,from Aerococcus viridans, expressed in E. coli, lyophilizate
Lactate 2-Monooxygenase (Lactateoxidase),from Pediococcus species, lyophilizate
Lactate 2-Monooxygenase (Lactateoxidase),from Pediococcus species, lyophilizate
Mab<CK-MM> Mix creatinine kinase isoenzyme MM
Mab Mix creatinine kinase isoenzyme MM
Creatine Kinase-MM Monoclonal Antibody (14.15)
Creatine Kinase-MM Monoclonal Antibody (14.15)
Creatine Kinase-MM Monoclonal Antibody (14.5)
Creatine Kinase-MM Monoclonal Antibody (14.5)
Creatine Kinase-MM Monoclonal Antibody (14.52)
Creatine Kinase-MM Monoclonal Antibody (14.52)