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P<font color='red'>NAS</font>惊人大发现!发烧竟能抗癌,“小病不断,大病不犯”或许不是谣传
近日,德国马克斯·普朗克免疫生物学和表观遗传学研究所Erika L. Pearce教授领衔的研究团队对这一疑问进行了科学的解答,该团队在《PNAS》杂志发表了一篇重要成果,发现机体体温的升高有益于优化CD8+T细胞的代谢活性和功能,增强线粒体蛋白的翻译效率,从而有效抵御癌细胞的侵袭。[查看]
http://www.cxbio.com/Article/pnasjrdfxfsjnkaxbbdd_1.html
Nature:被誉为“抗癌明星”的免疫疗法,可能是这类癌症患者的“催命符”
当地时间3月24日,由生物制药公司诺和诺德的Dominik Pfister领衔在《Nature》发表了一篇题为NASH limits anti-tumour surveillance in immunotherapy-treated HCC的文章,揭示了免疫疗法在HCC患者中产生不同疗效的原因。[查看]
http://www.cxbio.com/Article/naturebywkamxdmylfkn_1.html
新研究发现:人造甜味剂会促进全身炎症和脂肪肝的发展,不过有一种甜味剂例外…
近日,来自中国科学院精密测量科学与技术创新研究院和美国宾夕法尼亚州立大学的研究人员在《mSystems》上发表研究成果,发现NAS的摄入会显著减少小鼠肠道菌群中阿克曼氏菌的丰度,并降低芳香烃受体(AHR)激动剂水平,促进全身炎症和脂肪肝的发展。而另一种对健康无明显影响的天然甜味剂(新橙皮苷二氢查耳酮)或许能作为NAS和糖的替代品。[查看]
http://www.cxbio.com/Article/xyjfxrztwjhcjqsyzhzf_1.html
Viruses揭示:新冠病毒可藏匿于小鼠大脑,或能解释COVID-19患者康复后病情复发之谜
近日, Viruses发表了一篇题为Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 Mice的文章,发现SARS-CoV-2鼻内感染K18-hACE2小鼠会引起严重的神经系统疾病。[查看]
http://www.cxbio.com/Article/virusesjsxgbdkcnyxsd_1.html
P<font color='red'>NAS</font>:黑人新生儿在白人医生的照护下死亡的可能性要高出三倍
在一项新的研究中,来自美国多家研究机构的研究人员发现与美国全国平均水平相比,新生的黑人婴儿当由白人医生照护时,刚出生就死亡的可能性要高出3倍。相关研究结果近期发表在PNAS期刊上,论文标题为“Physician–patient racial concordance and disparities in birthing mortality for newborns”。在这篇论文中,他们描述了他们对佛罗里达州医疗记录和照顾新生儿的医生种族的研究,以及他们取得的发现。[查看]
http://www.cxbio.com/Article/pnashrxsezbrysdzhxsw_1.html
P<font color='red'>NAS</font>:解读!科学家们有望利用一种新型的聚糖标记策略来揭秘肝脏中的免疫激活机制!
人类细胞会被一层膜包裹着,膜上覆盖有多种称之为聚糖(glycans)的糖分子,这些聚糖分子在机体健康和疾病发生过程中扮演着非常关键的作用,因此了解其特性就显得尤为重要了,由于其独特之处,科学家们并没有太多工具来研究聚糖分子的功能以及其在机体中的相互作用。[查看]
http://www.cxbio.com/Article/pnasjdkxjmywlyyzxxdj_1.html
P<font color='red'>NAS</font>:P<font color='red'>NAS</font>解读!科学家们有望利用一种新型的聚糖标记策略来揭秘肝脏中的免疫激活机制!
近日,一篇发表在国际杂志Proceedings of the National Academy of Sciences上题为“Mapping glycan-mediated galectin-3 interactions by live cell proximity labeling”的研究报告中,来自斯克里普斯研究所等机构的科学家们通过研究提出了一种新型策略来捕获聚糖分子和人类肝脏细胞中特殊蛋白激活子之间的相互作用,这样一来,研究人员就能应用新技术来理解肝脏疾病的发生机制和机体的免疫激活机制。[查看]
http://www.cxbio.com/Article/pnaspnasjdkxjmywlyyz_1.html
P<font color='red'>NAS</font>:共享蛋白质指纹信息有助于治疗遗传性心脏病
肥厚型心肌病是最常见的遗传性心脏病,其特征是异常增厚的心肌会阻塞血液流动并导致年轻人猝死。[查看]
http://www.cxbio.com/Article/pnasgxdbzzwxxyzyzlyc_1.html
P<font color='red'>NAS</font>:研究揭示胆固醇对细胞膜的影响
十多年来,科学家们已经接受胆固醇(细胞膜的关键成分)并不能统一影响不同类型的膜。但是,弗吉尼亚理工大学物理系助理教授Rana Ashkar领导的一项新研究发现,胆固醇实际上确实符合生物物理原理。[查看]
http://www.cxbio.com/Article/pnasyjjsdgcdxbmdyx_1.html
Fluorospark(R) 激酶/ADP 多重检测试剂盒(291-77401)
Fluorospark(R) 激酶/ADP 多重检测试剂盒(291-77401)Fluorospark(R) Kinase/ADP Multi-Assay Kit是和光(wako)与日本东京大学新药研究机构共同研发的ADP荧光检测试剂盒。拥有高通量筛选(HTS)必备的高灵敏度、高准确度、低成本、简便等特性。本产品不仅可检测激酶,同时可用于检测产生ADP的酶(如ATP酶、乙酰基—CoA羧化酶)的活性[查看]
http://www.cxbio.com/Article/291-77401_1.html
1篇Nature和1篇Cell论文揭示与帕金森病相关的蛋白LRRK2作用机制
一种难以捉摸的蛋白被许多人认为是全面了解遗传性帕金森病病因的关键,而且如今却更加清晰地成为人们关注的焦点。研究这种疾病的主要原因的科学家们将重点放在这种称为富含亮氨酸重复激酶2(leucine-rich repeat kinase 2, LRRK2)的蛋白的突变上。[查看]
http://www.cxbio.com/Article/1pnatureh1pcelllwjsy_1.html
Murine RNase Inhibitor(40 U/μL) 鼠源RNase抑制剂
西宝生物Murine RNase inhibitor 是以可溶形式在大肠杆菌中表达纯化的重组鼠源RNase抑制剂,能够广泛抑制各种RNase (RNase A,B,C),可与RNaseA、B、C非共价结合,形成1:1的复合物,具有广谱的RNase抑制活性.可在高达55℃的温度环境下保护RNA不受降解。[查看]
http://www.cxbio.com/Article/murinernaseinhibitor_1.html
P<font color='red'>NAS</font>:研究揭示系统性过敏反应的发生机制
最近一项研究中,慕尼黑的路德维希-马克西米利安大学(LMU)研究者们研究了肥大细胞如何调节其钙水平,从而使免疫反应得到控制。[查看]
http://www.cxbio.com/Article/pnasyjjsxtxgmfydfsjz_1.html
Sci Transl Med:新突破!科学家揭秘microRNA分子保护机体血管完整性的分子机制!
短链RNA分子(microRNAs,miRNAs)在基因表达的调节过程中扮演着非常关键的角色,miRNAs分子表达和功能的异常往往参与到了多种病理学过程中,包括诸如动脉粥样硬化等慢性疾病的发生等,miRNAs的调节性功能通常在细胞质中发生,在细胞质中其能与靶标RNA转录物相互作用从而来抑制蛋白质的产生并促进RNA转录物衰退。[查看]
http://www.cxbio.com/Article/scitranslmedxtpkxjjm_1.html
P<font color='red'>NAS</font>:研究揭示导致糖尿病与脂肪肝产生的分子机制
近日,由神户大学医学研究生院糖尿病与内分泌学部OGAWA Wataru教授和HOS??OOKA Tetsuya副教授领导的研究小组阐明了糖尿病和非酒精性脂肪性肝炎(NASH)发展的潜在机制。[查看]
http://www.cxbio.com/Article/pnasyjjsdztnbyzfgcsd_1.html
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Creatine Kinase-MM Monoclonal Antibody (14.15)
Creatine Kinase-MM Monoclonal Antibody (14.15)
Creatine Kinase-MM Monoclonal Antibody (14.5)
Creatine Kinase-MM Monoclonal Antibody (14.5)
Creatine Kinase-MM Monoclonal Antibody (14.52)
Creatine Kinase-MM Monoclonal Antibody (14.52)