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P<font color='red'>NAS</font>:重大进展!制定出利用CRISPR/Cas9高效编辑基因组规则
在一项新的研究中,来自美国约翰霍普金斯大学的研究人员将不同的供者DNA组合插入到人胚胎肾细胞中,这些细胞以其生长良好的能力和经常用于癌症研究中而为人所知。他们使用携带着编码一种绿色荧光蛋白的基因的供者DNA,当这种基因成功地插入到细胞基因组中时,这种绿色荧光蛋白就会在细胞的核膜上发出绿色荧光。相关研究结果于2017年11月27日在线发表在PNAS期刊上[查看]
http://www.cxbio.com/Article/pnaszdjzzdclycrisprc_1.html
P<font color='red'>NAS</font>:治疗癌症的新型抗体疗法
最近,来自Rush大学医学中心的研究者们发现,特定的癌症分子能够利用机体免疫系统的蛋白质分子延缓死亡。研究者们同时发现利用抗体中和这类分子能够杀伤肿瘤细胞,进一步缩小小鼠中肿瘤的体积。[查看]
http://www.cxbio.com/Article/pnaszlazdxxktlf_1.html
P<font color='red'>NAS</font>:鉴定出一种治疗HIV的潜在新方法
在一项新的研究中,来自美国南加州大学凯克医学院的研究人员发现靶向人蛋白而不是不断发生突变的病毒的医学疗法可能有朝一日有益于已对当前用来保持身体健康的“药物混合物”产生抵抗力的HIV感染者。相关研究结果近期发表在PNAS期刊上[查看]
http://www.cxbio.com/Article/pnasjdcyzzlhivdqzxff_1.html
P<font color='red'>NAS</font>:组织相容性复合体通过调节肠道微生物稳态保护机体不受I型糖尿病与其它自体免疫性疾病的影响
最近一项研究发现,一种保护机体抵抗自体免疫疾病,尤其是I型糖尿病的基因是通过改变肠道微生物的组成发挥功能的。小鼠水平的试验结果表明,发育关键时期如果体内的肠道微生物组受到抗生素的破坏之后,该基因保护机体免受I型糖尿病的作用会受到明显的影响。这一发现再次强调了婴幼儿应尽量避免接触抗生素的重要性。[查看]
http://www.cxbio.com/Article/pnaszzxrxfhttgdjcdws_1.html
FDA批准的寡核苷酸类药物及在研反义寡核苷酸类药物一览
寡核苷酸,是一类20个左右碱基的短链核苷酸的总称(包括脱氧核糖核酸DNA或核糖核酸RNA内的核苷酸)。寡核苷酸可以很容易地和它们的互补链结合,所以常用来作为探针确定DNA或RNA的结构;而其作为药物候选应用的研究则始于大约30年前,包括了反义寡核苷酸(ASOs),核酸适配体(apatmers)及近15年来对各类siRNAs的研究。这期间,医药工业界开展了大量的临床试验。截至2017年5月底,共有6类寡核苷酸类药物获得美国FDA批准上市应用,其中属于反义寡核苷酸的药物有四种,同时有大量药物处于不同阶段的临床研究中。[查看]
http://www.cxbio.com/Article/fdapzdghgslywjzyfygh_1.html
P<font color='red'>NAS</font> 发现治疗并预后恶性脑瘤潜在靶点
来自新加坡国立大学新加坡癌症科学研究所(CSI)的科学家们发现蛋白BCL6可能是预测多形性胶质母细胞瘤(GBM)病人预后的标记物,而GBM是脑瘤中恶性程度最高的肿瘤。[查看]
http://www.cxbio.com/Article/pnasfxzlbyhexnlqzbd_1.html
西宝生物Panasonic代理证书
西宝生物Panasonic代理证书[查看]
http://www.cxbio.com/Article/xbswpanasonicdlzs_1.html
「西宝生物」代理Panasonic【医用低温冰箱】
西宝生物专业代理并分销Panasonic品牌医用低温保存箱、医用药剂保存箱医用保存箱以及医用超低温保存箱等。日本SANYO(三洋)公司是世界专业的低温保存设备、培养设备、净化设备、干燥灭菌设备生产厂商。订购热线:400-021-8158[查看]
http://www.cxbio.com/Article/xbswzydlpanasonicyyd_1.html
P<font color='red'>NAS</font>:低糖饮食能够延缓眼部衰老疾病的发生
最近一项小鼠水平的研究指出,低糖饮食可以缓解衰老导致的视觉退化(AMD)的症状。在总体卡路里水平相当的前提下,高血糖饮食释放到血液中的糖分的速率明显要高于低糖饮食。[查看]
http://www.cxbio.com/Article/pnasdtysngyhybsljbdf_1.html
P<font color='red'>NAS</font>:躁郁症的内在分子机制
最近,一项由多个研究所的合作研究结果揭示了锂元素在治疗躁郁症患者中的分子机制。这项研究发表在《PNAS》杂志上,他们利用人源的诱导多能性干细胞追踪了锂元素反应的信号通路,并对躁郁症的发病机制有了更进一步的理解。[查看]
http://www.cxbio.com/Article/pnaszyzdnzfzjz_1.html
Cell:古老的酶AMCase保护哺乳动物免受肺部疾病
几丁质广泛地存在于几乎所有生物体内,如螃蟹腿、虾壳、真菌细胞壁等。酸性哺乳动物几丁质酶(acidic mammalian chitinase, AMCase)是一种古老的能分解几丁质的酶。在一项新的研究中,来自美国加州大学旧金山分校的研究人员发现几丁质促进肺部疾病产生,同时还发现AMCase可以延缓/预防这些疾病的发生,从而潜在地有助人们开发一系列治疗肺部疾病的药物。[查看]
http://www.cxbio.com/Article/cellgldmamcasebhbrdw_1.html
P<font color='red'>NAS</font>:揭示记忆T细胞产生之谜
如今,在一项新的研究中,来自美国密苏里大学医学院的研究人员鉴定出在记忆T细胞中运行的一种分子机制,经操纵后,这种机制可能在体内产生和维持更多的记忆T细胞。[查看]
http://www.cxbio.com/Article/pnasjsjytxbcszm_1.html
P<font color='red'>NAS</font>:首次利用CRISPR-Cas9对古生菌进行基因组编辑
在一项新的研究中,来自美国伊利诺伊大学厄巴纳-香槟分校的微生物学教授Bill Metcalf和博士后研究员Dipti Nayak首次记录了在古生菌(Archaea,也译作古细菌,或古菌)中使用CRISPR-Cas9介导的基因组编辑。他们的突破性工作有潜力在未来极大地加快研究这类有机体,包括对全球气候变化的影响。[查看]
http://www.cxbio.com/Article/pnassclycrisprcas9dg_1.html
P<font color='red'>NAS</font>:如何利用简单的血液检测来诊断癌症?
最近,一项发表在国际杂志Proceedings of the National Academy of Sciences上的研究报告中,来自普渡大学的研究人员通过研究表示,医生们未来或有望利用简单的血液检测来诊断和监测患者的癌症,从而或许就能够降低或消除一些侵入性手段的使用,文章中,研究者在血浆中鉴别出了一系列蛋白质,当这些蛋白水平升高时就意味着患者会患上癌症。[查看]
http://www.cxbio.com/Article/pnasrhlyjddxyjclzdaz_1.html
人类被太空辐射后基因会产生变化
据《自然》杂志官方网站报道,美国宇航局NASA对一对双胞胎宇航员进行了长达一年的身体研究,结果表明,太空旅行会导致人类基因表达发生异常变化,染色体端粒将会变长。[查看]
http://www.cxbio.com/Article/rlbtkfshjyhcsbh_1.html
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Creatine Kinase-MM Monoclonal Antibody (14.5)
Creatine Kinase-MM Monoclonal Antibody (14.52)
Creatine Kinase-MM Monoclonal Antibody (14.52)